Genova Diagnostics Tests – Fatigue

“Fatigue is generally defined as a lack of energy and motivation. Although fatigue can be a normal response to physical exertion, lack of sleep, or chronic stress, ongoing fatigue that is not relieved by factors such as rest, eating, or stress reduction may signal underlying physiologic imbalances or, in some cases, more serious disorders such as cardiovascular disease, infection or anemia. There are numerous possible causes of fatigue; laboratory evaluation can help pinpoint many of them.” From Genova Diagnostics website,


Tests from Genova Diagnostics cover the following possible causes of fatigue: (the following are quotes from

  • Nutrition: Imbalances in key vitamins, minerals, essential fats, or amino acids can directly impact energy production and endurance.
  • Adrenal Hormones: Chronically low or high levels of stress hormone can wear the body down and produce feelings of exhaustion.
  • Thyroid Function: Low thyroid function goes hand in hand with reduced metabolism and fatigue.
  • Amino Acids: Fatigue can result from deficiencies of key amino acids involved in muscle and thyroid function, maintenance of blood sugar, and detoxification.
  • Menopause: Fatigue can occur in peri- and post-menopause, as a result of hormone imbalances and sleep difficulties. 
  • Cellular Energy: About 90% of the body’s energy is generated by a cellular energy cycle that depends on a healthy balance of organic acids.
  • Oxidative Stress: Unstable free radical molecules can damage the mitochondria, the site of energy production within the cells.
  • Heavy Metal Toxicity: Exposures to certain heavy metal toxins may result in disrupted energy production in the body.
  • Fatty Acids: Imbalances in essential fatty acids may promote inflammation and impair cellular function, resulting in chronic fatigue.
  • Allergies: Chronic immune reactions to allergens in the diet or environment often go hand-in-hand with fatigue.
  • Celiac Disease: Malabsorption resulting from celiac disease can result in deficiencies of key nutrients for energy, such as vitamin B12 and iron.
  • Digestive Function: Fatigue can be secondary to maldigestion and malabsorption of important nutrients for energy.
  • Yeast Overgrowth: Some cases of chronic fatigue can be traced to intestinal overgrowth of Candida albicans and toxin production.
  • Parasite Infection: Fatigue that accompanies gastrointestinal symptoms may signal a parasite infection in the intestine.
  • Intestinal Permeability: Chronic escape of toxins from the bowel due to intestinal irritants can trigger inflammation and fatigue.
  • Bacterial Overgrowth of the Small Intestine: Excessive bacteria in the small bowel may compromise absorption, resulting in anemia and fatigue.
  • Viral Infection: Fatigue is the hallmark symptom of chronic viral infections, such as Epstein Barr Virus or mononucleosis.
  • Male Hormones: Low energy often accompanies the reductions in testosterone and DHEA that occur in many middle-aged men.
  • Growth Hormone and IGF-1: Deficiencies of growth hormone and IGF-1 (which mediate GH’s actions) often result in poor exercise endurance and fatigue.
  • Cardiovascular Health: Chronic fatigue may signal a more serious disorder like cardiovascular disease, identifiable through key lab tests.
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